Antiplasmin
| Profile or Test Panel |
Bleeding Diathesis with a Normal APTT/PT Profile
Fibrinolysis Evaluation Profile
|
| Method | Chromogenic |
| Test Information | Alpha-2-antiplasmin, a naturally-occurring inhibitor of fibrinolysis, is measured using a chromogenic substrate. Levels are reduced in hereditary alpha-2-antiplasmin deficiency, a rare autosomal recessive bleeding disorder. Some heterozygous individuals (40-60%) have mild bleeding tendencies. Acquired deficiencies include liver disease, disseminated intravascular coagulation (DIC), and thrombolytic therapy. |
| Sample Requirements | Whole Blood: 3.2% Sodium Citrated (blue top) OR Frozen Plasma |
| Requested Volume | Two 5 ml 3.2 sodium citrated (blue top) tubes as whole blood OR Frozen plasma in 4 X 1mL aliquots in plastic tubes |
| Minimum Volume or Pediatric volume | Frozen Plasma: at least 0.5ml in 2 plastic tubes. |
| Sample Information | Whole blood is preferred for testing but if it is not possible to send whole blood tubes TO ARRIVE HERE WITHIN 3 HOURS of collection then send frozen plasma. To prepare plasma centrifuge blue top tubes at 1500g for 15 minutes and remove the plasma and centrifuge a second time at 1500g for an additional 15 minutes. Aliquot approximately 1 ml of plasma into 4 plastic tubes, and freeze. |
| Shipping Information | Whole Blood: Send at ambient temperature (18-25C) and must be received within the lab in less than or equal to 3 hours after collection. Frozen Plasma: send on dry ice |
| Requisition Form | RFT- Hemostasis Reference Laboratory |
| Transaction Code | 3230-04 |
| CPT Codes | 85410 |
| Test Schedule | Monday – Friday |
| Turn around Time (analytic time) | 5 Business Days |
| Report/ Results | Fax number required to receive report |